Acute Myeloid Leukemia Research Today is a free monthly online journal that collates and summarizes the latest research about Acute Myeloid Leukemia, including details on aml, symptoms, treatment, information.

CREB: the unindicted cancer co-conspirator.

Conkright MD, Montminy M

The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA; Present Address: The Scripps Florida Research Institute 5353 Parkside Drive Jupiter, Florida 33458, USA.

The transcription factor cAMP response-element binding protein (CREB) participates in a diverse array of cellular processes, including survival, proliferation and glucose metabolism. A new report by Shankar et al. shows that patients with acute myeloid leukemia (AML) have a greater incidence of relapse when intracellular levels of CREB are elevated. By enhancing expression of certain cell-cycle genes, CREB appears to promote growth-factor-independent proliferation and survival of myeloid cells. The results provide new insights into CREB function and suggest potential avenues for therapeutic intervention.

Published 9 September 2005 in Trends Cell Biol, 15(9): 457-9.
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