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Partial tandem duplication of MLL gene in acute myeloid leukemia with translocation (11;17)(q23;q12-21).

Yamamoto S, Nishi M, Taniguchi K, Imayoshi M, Ogata Y, Iwanaga M, Sakai N, Hamasaki Y, Ishii E

Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan.

Translocation 11q23 and MLL gene rearrangements are commonly observed in acute myeloid leukemia (AML) in association with the myelomonocytic or monocytic feature. We describe a case involving a 15-year-old patient with AML characterized by leukemic cells exhibiting translocation (11;17)(q23;q12-21) and MLL gene rearrangement. No fusion partner gene of the MLL gene was identified, including RARalpha(17q12) or AF17 (17q21); however, a partial tandem duplication of the MLL exon 11/exon 10 was detected in leukemic cells via a 3'RACE method for detection of unknown partner genes. The patient has been in remission for more than 2 years without hematopoietic stem cell transplantation. Am. J. Hematol. 80:46-49, 2005. (c) 2005 Wiley-Liss, Inc.

Published 7 September 2005 in Am J Hematol, 80(1): 46-9.
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