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Translocation (10;17)(p15;q21) is a recurrent anomaly in acute myeloblastic leukemia.

Tempescul A, Guillerm G, Douet-Guilbert N, Morel F, Le Bris MJ, De Braekeleer M

Department of Clinical Hematology, Institute of Cancerology and Hematology, CHU Morvan, Avenue Foch, 29609 Brest, France.

We report here two cases of patients with acute myeloblastic leukemia, type M1 (FAB classification), associated with a t(10;17)(p15;q21). Fluorescence in situ hybridization with the LSI PML/RARA dual-color probe showed the breakpoint to be distal to the RARA locus. Four other patients with this translocation have been reported, three of them having acute undifferentiated or poorly differentiated leukemia.

Published 18 December 2006 in Cancer Genet Cytogenet, 172(1): 74-6.
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