Acute Myeloid Leukemia Research Today is a free monthly online journal that collates and summarizes the latest research about Acute Myeloid Leukemia, including details on aml, symptoms, treatment, information.

A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia.

Alonso CN, Longo PL, Gallego MS, Medina A, Felice MS

Molecular Biology Laboratory, Department of Hematology-Oncology, Hospital de Pediatría SAMIC "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina. calonso@garrahan.gov.ar

MLL-AF9 is the most frequent MLL rearrangement in childhood acute myeloid leukemia (AML) and it may be also found in acute lymphoblastic leukemia (ALL) of patients younger than 1-year-old (infants). We report a novel AF9 breakpoint site, located between previously reported sites A and B, detected in an infant who was diagnosed with AML-FAB M5. The occurrence of this new breakpoint should be considered when designing RT-PCR assays for the screening of MLL abnormalities. The precise characterization of the MLL-AF9 transcript is important to carry out the minimal residual disease analysis during the follow-up of the patients.

Published 25 February 2008 in Pediatr Blood Cancer, 50(4): 869-71.
Full-text of this article is available online (may require subscription).

© 2004-2008 Acute Myeloid Leukemia Research Today. All Rights Reserved.